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Featured Article

Healing With Ketamine & Psychdelics

It’s said that science progresses “one gravestone at a time,” since major changes in theoretical perspective usually require a new generation or more to take hold.

Psychiatry, in contrast, is in the midst of a massive shift: We’re experiencing a veritable psychedelic revolution, as drugs like MDMA, psilocybin, and ketamine offer new hope for treating severe mental anguish.

Research Papers

Ketamine as a novel treatment for major depressive disorder and bipolar depression: a systematic review and quantitative meta-analysis

Ellen E. Lee, M.D., Megan P. Della Selva, M.D., Anson Liu, M.D., Seth Himelhoch, M.D., M.P.H.

General Hospital Psychiatry, Published: 8 January 2015

Ketamine as a rapid-acting agent for suicidal ideation: A meta-analysis

Francesco Bartoli, Ilaria Riboldi, Cristina Crocamoa, Carmen Di Britaa, Massimo Clerici, Giuseppe Carràa

Neuroscience and Biobehavioral Reviews, Published: 23 March 2017

Efficacy of Ketamine in Bipolar Depression: Systematic Review and Meta-analysis

Ajay K. Parsaik, MD, MS, Balwinder Singh, MD, MS, Darrow Khosh-Chashm, MD, Soniya S. Mascarenhas, RN

Journal of Psychiatric Practice, Published: November 2015

Ketamine as a Fast Acting Antidepressant: Current Knowledge and Open Questions

Giacomo Salvadore & Jaskaran B. Singh

CNS Neuroscience & Therapeutics, Published: 18 February 2013

A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression

Carlos A. Zarate, Jr, MD; Jaskaran B. Singh, MD; Paul J. Carlson, MD; Nancy E. Brutsche, MSN; Rezvan Ameli, PhD; David A. Luckenbaugh, MA; Dennis S. Charney, MD; Husseini K. Manji, MD, FRCPC

Arch Gen Psychiatry, Published: August 2006

Synaptic Loss and the Pathophysiology of PTSD: Implications for Ketamine as a Prototype Novel Therapeutic

John H. Krystal, Chadi G. Abdallah, Lynette A. Averill, Benjamin Kelmendi, Ilan Harpaz-Rotem, Gerard Sanacora, Steven M. Southwick, and Ronald S. Duman

Curr Psychiatry Rep, Published: 18 April 2018

Efficacy of Intravenous Ketamine for Treatment of Chronic Posttraumatic Stress Disorder A Randomized Clinical Trial

Adriana Feder, MD; Michael K. Parides, PhD; James W. Murrough, MD; Andrew M. Perez, MD; Julia E. Morgan, BA; Shireen Saxena, MScPH; Katherine Kirkwood, MS; Marije aan het Rot, PhD; Kyle A. B. Lapidus, MD, PhD; Le-Ben Wan, MD, PhD; Dan Iosifescu, MD; Dennis S. Charney, MD

JAMA Psychiatry, Published: 16 April 2014

Ketamine’s dose-related effects on anxiety symptoms in patients with treatment refractory anxiety disorders

Andrew Gray, Neil Mcnaughton

Journal of Psychopharmacology, Published: April 2017

Ketamine reduces muscle pain, temporal summation, and referred pain in fibromyalgia patients

Thomas Graven-Nielsena, Sally Aspegren Kendallb, Karl G. Henriksson, Mats Bengtssone, Jan SoÈrensen, Anders Johnso, BjoÈrn Gerdle, Lars Arendt-Nielsen

Elsevier Science B.V, Published: 29 November 1999

Ketamine and Peripheral Inflammation

Marc De Kock, Sebastien Loix, Patricia Lavand’homme

CNS Neuroscience & Therapeutics, Published: 1 March 2013

Outpatient intravenous ketamine for the treatment of complex regional pain syndrome: A double-blind placebo controlled study

Robert J. Schwartzman, Guillermo M. Alexander, John R. Grothusen, Terry Paylor, Erin Reichenberger, Marielle Perreault

PAIN, Published: 18 August 2009

Ketamine produces effective and long-term pain relief in patients with Complex Regional Pain Syndrome Type 1

Marnix J. Sigtermans, Jacobus J. van Hilten, Martin C.R. Bauer, M. Sesmu Arbous, Johan Marinus, Elise Y. Sarton, Albert Dahan

PAIN, Published: 18 June 2009

Intravenous ketamine for subacute treatment of refractory chronic migraine: a case series

Clinton Lauritsen, Santiago Mazuera, Richard B. Lipton and Sait Ashina

The Journal of Headache and Pain, Published: 2016

Glutamate and Its Receptors as Therapeutic Targets for Migraine

Jan Hoffmann, Andrew Charles

The American Society for Experimental NeuroTherapeutics, Published: 5 March 2018

Efficacy of Ketamine in the Treatment of Substance Use Disorders: A Systematic Review

Jennifer L. Jones, Camilo F. Mateus, Robert J. Malcolm, Kathleen T. Brady, and Sudie E. Back

frontiers in Psychiatry, Published: 24 July 2018

Ketamine for the treatment of addiction: evidence and potential mechanisms

Ivan Ezquerra-Romano, W. Lawn, E. Krupitsky, C.J.A. Morgan

Elsevier, Published: 12 January 2018

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